Wigan striker Will Keane was called up for the first time in Ireland for the October games against Azerbaijan and Qatar.
England’s twin brother and Everton defender Michael, 28, represents England until the age of 20, but in February 2019 he announced his intention to play for the Republic.
He qualified for Ireland thanks to his father, and as Stephen Kenny’s side wanted to score, Kane now had his chance.
Ireland face Azerbaijan in the World Cup qualifiers in Baku on October 9 and three days later face Qatar in Dublin in a friendly match.
But there’s no room for Lincoln forward Anthony Scully, who has scored 10 goals this season.
Sheffield United defender Enda Stevens, Derby midfielder Jason Knight and Rotherham winger Chiduzi Ogbeni returned to the squad after injury excluded them from international games in September.
But captain Seamus Coleman and defenseman Dar O’Shea were sidelined with injury.
Young Norwich defender Andrew Aumobamidel, who made his debut against Portugal, retained his seat but goalkeeper Darren Randolph was ruled out again.
The Republic side have scored just two points in five qualifying round matches so far.
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